Suspected non-Alzheimer disease pathophysiology—concept and controversy
Identifieur interne : 001687 ( Main/Exploration ); précédent : 001686; suivant : 001688Suspected non-Alzheimer disease pathophysiology—concept and controversy
Auteurs : Clifford R. Jack ; David S. Knopman ; Gaël Chételat ; Dennis Dickson ; Anne M. Fagan ; Giovanni B. Frisoni ; William Jagust ; Elizabeth C. Mormino ; Ronald C. Petersen ; Reisa A. Sperling ; Wiesje M. Van Der Flier ; Victor L. Villemagne ; Pieter J. Visser ; Stephanie J. B. VosSource :
- Nature reviews. Neurology [ 1759-4758 ] ; 2016.
Descripteurs français
- KwdFr :
- Encéphale (anatomopathologie), Encéphale (physiopathologie), Humains, Maladie d'Alzheimer (anatomopathologie), Maladie d'Alzheimer (diagnostic), Maladie d'Alzheimer (physiopathologie), Marqueurs biologiques (métabolisme), Troubles de la cognition (anatomopathologie), Troubles de la cognition (diagnostic), Troubles de la cognition (physiopathologie), Troubles de la cognition (étiologie), Vieillissement (anatomopathologie), Vieillissement (physiologie), Vieillissement (psychologie).
- MESH :
- anatomopathologie : Encéphale, Maladie d'Alzheimer, Troubles de la cognition, Vieillissement.
- diagnostic : Maladie d'Alzheimer, Troubles de la cognition.
- métabolisme : Marqueurs biologiques.
- physiologie : Vieillissement.
- physiopathologie : Encéphale, Maladie d'Alzheimer, Troubles de la cognition.
- psychologie : Vieillissement.
- étiologie : Troubles de la cognition.
- Humains.
English descriptors
- KwdEn :
- Aging (pathology), Aging (physiology), Aging (psychology), Alzheimer Disease (diagnosis), Alzheimer Disease (pathology), Alzheimer Disease (physiopathology), Biomarkers (metabolism), Brain (pathology), Brain (physiopathology), Cognition Disorders (diagnosis), Cognition Disorders (etiology), Cognition Disorders (pathology), Cognition Disorders (physiopathology), Humans.
- MESH :
- chemical , metabolism : Biomarkers.
- diagnosis : Alzheimer Disease, Cognition Disorders.
- etiology : Cognition Disorders.
- pathology : Aging, Alzheimer Disease, Brain, Cognition Disorders.
- physiology : Aging.
- physiopathology : Alzheimer Disease, Brain, Cognition Disorders.
- psychology : Aging.
- Humans.
Abstract
Suspected non-Alzheimer disease pathophysiology (SNAP) is a biomarker-based concept that applies to individuals with normal levels of amyloid-β biomarkers in the brain, but in whom biomarkers of neurodegeneration are abnormal. The term SNAP has been applied to individuals who are clinically normal for their age and to individuals with mild cognitive impairment, but is applicable to any amyloid-negative, neurodegeneration-positive individual regardless of clinical status, except when the pathology underlying neurodegeneration can be confidently inferred from the clinical presentation. SNAP is present in ~23% of clinically normal individuals aged >65 years and in ~25% of mildly cognitively impaired individuals.
Url:
DOI: 10.1038/nrneurol.2015.251
PubMed: 26782335
PubMed Central: 4784257
Affiliations:
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Jack</name></author><author><name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S." last="Knopman">David S. Knopman</name></author><author><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chételat">Gaël Chételat</name></author><author><name sortKey="Dickson, Dennis" sort="Dickson, Dennis" uniqKey="Dickson D" first="Dennis" last="Dickson">Dennis Dickson</name></author><author><name sortKey="Fagan, Anne M" sort="Fagan, Anne M" uniqKey="Fagan A" first="Anne M." last="Fagan">Anne M. Fagan</name></author><author><name sortKey="Frisoni, Giovanni B" sort="Frisoni, Giovanni B" uniqKey="Frisoni G" first="Giovanni B." last="Frisoni">Giovanni B. Frisoni</name></author><author><name sortKey="Jagust, William" sort="Jagust, William" uniqKey="Jagust W" first="William" last="Jagust">William Jagust</name></author><author><name sortKey="Mormino, Elizabeth C" sort="Mormino, Elizabeth C" uniqKey="Mormino E" first="Elizabeth C." last="Mormino">Elizabeth C. Mormino</name></author><author><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C." last="Petersen">Ronald C. Petersen</name></author><author><name sortKey="Sperling, Reisa A" sort="Sperling, Reisa A" uniqKey="Sperling R" first="Reisa A." last="Sperling">Reisa A. Sperling</name></author><author><name sortKey="Van Der Flier, Wiesje M" sort="Van Der Flier, Wiesje M" uniqKey="Van Der Flier W" first="Wiesje M." last="Van Der Flier">Wiesje M. Van Der Flier</name></author><author><name sortKey="Villemagne, Victor L" sort="Villemagne, Victor L" uniqKey="Villemagne V" first="Victor L." last="Villemagne">Victor L. Villemagne</name></author><author><name sortKey="Visser, Pieter J" sort="Visser, Pieter J" uniqKey="Visser P" first="Pieter J." last="Visser">Pieter J. Visser</name></author><author><name sortKey="Vos, Stephanie J B" sort="Vos, Stephanie J B" uniqKey="Vos S" first="Stephanie J. B." last="Vos">Stephanie J. B. Vos</name></author></analytic><series><title level="j">Nature reviews. Neurology</title><idno type="ISSN">1759-4758</idno><idno type="eISSN">1759-4766</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aging (pathology)</term><term>Aging (physiology)</term><term>Aging (psychology)</term><term>Alzheimer Disease (diagnosis)</term><term>Alzheimer Disease (pathology)</term><term>Alzheimer Disease (physiopathology)</term><term>Biomarkers (metabolism)</term><term>Brain (pathology)</term><term>Brain (physiopathology)</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (pathology)</term><term>Cognition Disorders (physiopathology)</term><term>Humans</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Encéphale (anatomopathologie)</term><term>Encéphale (physiopathologie)</term><term>Humains</term><term>Maladie d'Alzheimer (anatomopathologie)</term><term>Maladie d'Alzheimer (diagnostic)</term><term>Maladie d'Alzheimer (physiopathologie)</term><term>Marqueurs biologiques (métabolisme)</term><term>Troubles de la cognition (anatomopathologie)</term><term>Troubles de la cognition (diagnostic)</term><term>Troubles de la cognition (physiopathologie)</term><term>Troubles de la cognition (étiologie)</term><term>Vieillissement (anatomopathologie)</term><term>Vieillissement (physiologie)</term><term>Vieillissement (psychologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphale</term><term>Maladie d'Alzheimer</term><term>Troubles de la cognition</term><term>Vieillissement</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Alzheimer Disease</term><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Maladie d'Alzheimer</term><term>Troubles de la cognition</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Marqueurs biologiques</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Aging</term><term>Alzheimer Disease</term><term>Brain</term><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Vieillissement</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aging</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Encéphale</term><term>Maladie d'Alzheimer</term><term>Troubles de la cognition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Alzheimer Disease</term><term>Brain</term><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Vieillissement</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Aging</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Troubles de la cognition</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Suspected non-Alzheimer disease pathophysiology (SNAP) is a biomarker-based concept that applies to individuals with normal levels of amyloid-β biomarkers in the brain, but in whom biomarkers of neurodegeneration are abnormal. The term SNAP has been applied to individuals who are clinically normal for their age and to individuals with mild cognitive impairment, but is applicable to any amyloid-negative, neurodegeneration-positive individual regardless of clinical status, except when the pathology underlying neurodegeneration can be confidently inferred from the clinical presentation. SNAP is present in ~23% of clinically normal individuals aged >65 years and in ~25% of mildly cognitively impaired individuals. <italic>APOE4</italic> is underrepresented in individuals with SNAP compared with amyloid-positive individuals. Clinically normal and mildly impaired individuals with SNAP have worse clinical and/or cognitive outcomes than individuals with normal levels of neurodegeneration and amyloid-β biomarkers. In this Perspectives article we describe the available data on SNAP and address topical controversies in the field.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chételat">Gaël Chételat</name><name sortKey="Dickson, Dennis" sort="Dickson, Dennis" uniqKey="Dickson D" first="Dennis" last="Dickson">Dennis Dickson</name><name sortKey="Fagan, Anne M" sort="Fagan, Anne M" uniqKey="Fagan A" first="Anne M." last="Fagan">Anne M. Fagan</name><name sortKey="Frisoni, Giovanni B" sort="Frisoni, Giovanni B" uniqKey="Frisoni G" first="Giovanni B." last="Frisoni">Giovanni B. Frisoni</name><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R." last="Jack">Clifford R. Jack</name><name sortKey="Jagust, William" sort="Jagust, William" uniqKey="Jagust W" first="William" last="Jagust">William Jagust</name><name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S." last="Knopman">David S. Knopman</name><name sortKey="Mormino, Elizabeth C" sort="Mormino, Elizabeth C" uniqKey="Mormino E" first="Elizabeth C." last="Mormino">Elizabeth C. Mormino</name><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C." last="Petersen">Ronald C. Petersen</name><name sortKey="Sperling, Reisa A" sort="Sperling, Reisa A" uniqKey="Sperling R" first="Reisa A." last="Sperling">Reisa A. Sperling</name><name sortKey="Van Der Flier, Wiesje M" sort="Van Der Flier, Wiesje M" uniqKey="Van Der Flier W" first="Wiesje M." last="Van Der Flier">Wiesje M. Van Der Flier</name><name sortKey="Villemagne, Victor L" sort="Villemagne, Victor L" uniqKey="Villemagne V" first="Victor L." last="Villemagne">Victor L. Villemagne</name><name sortKey="Visser, Pieter J" sort="Visser, Pieter J" uniqKey="Visser P" first="Pieter J." last="Visser">Pieter J. Visser</name><name sortKey="Vos, Stephanie J B" sort="Vos, Stephanie J B" uniqKey="Vos S" first="Stephanie J. B." last="Vos">Stephanie J. B. Vos</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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